BDNF Val66Met polymorphism and the affective
نویسندگان
چکیده
منابع مشابه
Bdnf Val66met Polymorphism Modulates Sleep Intensity
335 BDNF Genotype and Sleep Intensity—Bachmann et al Moreover, in adult rats, the degree of exploratory behavior predicts the level of BDNF as well as of SWA during subsequent sleep.10 Finally, pharmacological experiments such as injections of exogenous BDNF, an anti-BDNF antibody, and an inhibitor of tyrosine kinase B receptor, the high-affinity BDNF receptor, consistently suggest that this re...
متن کاملAssociation between the BDNF Val66Met Polymorphism and Chronicity of Depression
OBJECTIVE Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD). METHODS Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces...
متن کاملA BDNF Val66Met Polymorphism and Ketamine-induced Rapid Antidepressant Action
TO THE EDITOR Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) plays a key role in the patho-physiology of major depression, as well as the therapeutic action of antidepressants. 1,2) Serum levels of BDNF in drug naïve patients with major depression are significantly lower than those in normal controls. Additionally, serum levels of BDNF in drug naïve patients can be...
متن کاملThe BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein. In human subjects, the met allele was associated with poorer episodic memory, abnormal hippocampal activation assayed with fMRI, and low...
متن کاملVariant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory.
Brain-derived neurotrophic factor (BDNF) plays important roles in activity-dependent plasticity processes, such as long-term potentiation, learning, and memory. The recently reported human BDNF Val66Met (BDNF(Met)) polymorphism has been shown to lead to altered hippocampal volume and impaired hippocampal-dependent memory and is associated with a variety of neuropsychiatric disorders. There are ...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2009
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.195.2.179